HuagongsheHuagongshe Chemistry Print Report · For research reference only
{5-Methyl-6-[2-(4-trifluoromethyl-benzyloxy)-benzyloxy]-benzo[b]thiophen-3-yl}-acetic acid methyl ester → {5-Methyl-6-[2-(4-trifluoromethyl-benzyloxy)-benzyloxy]-benzo[b]-thiophen-3-yl}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {5-Methyl-6-[2-(4-trifluoromethyl-benzyloxy)-benzyloxy]-benzo[b]thiophen-3-yl}-acetic acid methyl ester | HCID 20770845 | — |
| Reactant | [2-(4-Trifluoromethyl-benzyloxy)-phenyl]-methanol | HCID 22279996 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | {5-Methyl-6-[2-(4-trifluoromethyl-benzyloxy)-benzyloxy]-benzo[b]-thiophen-3-yl}-acetic acid | HCID 22504750 | 86% |
Reaction Steps
The title compound was prepared using compound 78D from the preceding step and compound 7A in a manner analogous to compound 77. Thus, chromatography on silica gel in ethyl acetate followed by trituration in ethanol afforded 0.16 g (86% yield) of the title compound as a white solid; mp 157-158° C. Calc for C26H21F3O4S: C, 64.19; H, 4.35; found: C, 63.43; H, 4.04.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06875780B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-0dca97fb486c441f83d2931894546ba3 |
| Source note | uspto-grants-2005_04 |