Ethanolamine → 2-[[(3-Chloro-2-fluorophenyl)methyl]thio]4-[(2-hydroxyethyl)amino]-7(8H)-pteridinone

HRID 1814246Notes

Reaction equation

HRID 1814246 reaction equation
Br[C:2]1[C:11]2[N:10]=[CH:9][C:8](=[O:12])[NH:7][C:6]=2[N:5]=[C:4]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:16]=2[F:22])[N:3]=1.[CH2:23]([CH2:25][NH2:26])[OH:24]>>[Cl:21][C:17]1[C:16]([F:22])=[C:15]([CH2:14][S:13][C:4]2[N:3]=[C:2]([NH:26][CH2:25][CH2:23][OH:24])[C:11]3[N:10]=[CH:9][C:8](=[O:12])[NH:7][C:6]=3[N:5]=2)[CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 225059834-Bromo-2-[[(3-chloro-2-fluorophenyl)methyl]thio]-7(8H)-pteridinone

Product 1

HCID 225059342-[[(3-Chloro-2-fluorophenyl)methyl]thio]4-[(2-hydroxyethyl)amino]-7(8H)-pteridinone

Procedure

The titled compound (51 mg) was prepared by the method of Example 6, step (f) using the product from Example 6, step (e) (75 mg) and ethanolamine (25 μl).

Sources & evidence

ORD record
ord-8e625f6983434f6dacf77c3fd110c053
Source dataset
uspto-grants-2005_04
Patent number
US06875868B2

Reaction notes

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