HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-[[(3-chloro-2-fluorophenyl)methyl]thio]-7(8H)-pteridinone → [(2r)-2-[[2-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7,8-dihydro-7-oxo-4-pteridinyl]amino]propyl]-carbamic acid, 1,1-dimethylethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-[[(3-chloro-2-fluorophenyl)methyl]thio]-7(8H)-pteridinone | HCID 22505983 | — |
| Reactant | tert-butyl N-((2R)-2-aminopropyl)carbamate | HCID 45072491 | — |
| Product | [(2r)-2-[[2-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7,8-dihydro-7-oxo-4-pteridinyl]amino]propyl]-carbamic acid, 1,1-dimethylethyl ester | HCID 91168650 | 89.8% |
Reaction Steps
The titled compound (83 mg) was prepared by the method of Example 6, step (f) using the product from Example 6, step (e) (75 mg) and the product from example 9, step (d) (72 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06875868B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-d9ab3e8edd8245d2b7e88fc35c551874 |
| Source note | uspto-grants-2005_04 |