(3-Chloro-4-methoxyphenyl)methanethiol → 4-Amino-2-[[(3-chloro-4-methoxyphenyl)methyl]thio]-7(8H)-pteridinone

HRID 1814252Notes

Reaction equation

HRID 1814252 reaction equation
[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8](=[O:12])[NH:7][C:6]=2[N:5]=[C:4](S(CC2C=CC=CC=2)(=O)=O)[N:3]=1.[Cl:23][C:24]1[CH:25]=[C:26]([CH2:32][SH:33])[CH:27]=[CH:28][C:29]=1[O:30][CH3:31]>>[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8](=[O:12])[NH:7][C:6]=2[N:5]=[C:4]([S:33][CH2:32][C:26]2[CH:27]=[CH:28][C:29]([O:30][CH3:31])=[C:24]([Cl:23])[CH:25]=2)[N:3]=1

Participants

3

Reactant 2

HCID 12347049(3-Chloro-4-methoxyphenyl)methanethiolHCID 225059954-Amino-2-[(phenylmethyl)sulfonyl]-7(8H)-pteridinone

Product 1

HCID 225060224-Amino-2-[[(3-chloro-4-methoxyphenyl)methyl]thio]-7(8H)-pteridinoneYield 102%

Procedure

The subtitled compound (1.36 g) was prepared by the method of Example 6, step (d) using the product from Example 6, step (b) (1.21 g) and 3-chloro-4-methoxy-benzenemethanethiol (0.72 g).

Sources & evidence

ORD record
ord-8d8f49fa9ba940938b5888241fd3e75f
Source dataset
uspto-grants-2005_04
Patent number
US06875868B2

Reaction notes

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