(1,2-Oxazol-5-yl)methanethiol → 4-[[(1R)-2-Hydroxy-1-methylethyl]amino]-2-[(5-isoxazolylmethyl)thio]-7(8H)-pteridinone

HRID 1814257Notes

Reaction equation

HRID 1814257 reaction equation
F[C:2]1[C:7](F)=CC=C[C:3]=1[CH2:9][S:10]([C:13]1[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=1)(=O)=O.[O:29]1C(CS)=CC=[N:30]1>>[OH:26][CH2:25][C@H:24]([NH:23][C:21]1[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=[C:13]([S:10][CH2:9][C:3]2[O:29][N:30]=[CH:7][CH:2]=2)[N:22]=1)[CH3:27]

Participants

3

Reactant 2

HCID 15646082(1,2-Oxazol-5-yl)methanethiolHCID 688171932-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

Product 1

HCID 688153814-[[(1R)-2-Hydroxy-1-methylethyl]amino]-2-[(5-isoxazolylmethyl)thio]-7(8H)-pteridinoneYield 46.8%

Procedure

The titled compound (0.038 g) was prepared by the method of Example 13, step (c) using the product from Example 13, step (a) (0.10 g) and 5-isoxazolylmethylmercaptan (0.057 g).

Sources & evidence

ORD record
ord-1ce814bc3d9648249797053e4cdb2743
Source dataset
uspto-grants-2005_04
Patent number
US06875868B2

Reaction notes

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