1-[2-(5-Fluoro-2-nitrophenoxy)ethyl]naphthalene → HCID 22504195, compound

Participants

Reaction Steps

A solution of 1-[2-(5-fluoro-2-nitro-phenoxy)-ethyl]-naphthalene (24.63 g, 79.10 mmol) in THF (200 mL) was shaken with Raney nickel (3.0 g) under H2 (55 psi) for 2 h using Parr apparatus. The reaction mixture was filtered through celite and concentrated. 4-Fluoro-2-(2-naphthalen-1-yl-ethoxy)-phenylamine (21.0 g, 94%) was obtained as a light-yellow solid. 1H NMR (CDCl3, 400 MHz) 8.12 (d, 1H), 7.84 (d, 1H), 7.77 (d, 1H), 7.57-7.42 (m, 4H), 6.60-6.45 (m, 3H), 4.31 (t, 2H), 3.59 (t, 2H).

Provenance & Evidence