HCID 69692575, compound → HCID 69692523, compound

Participants

Reaction Steps

A solution of (S)-3-[4-acetylamino-2-(2-quinolin-5-yl-ethoxy)-benzenesulfonylamino]-3-cyano-propionic acid tert-butyl ester (0.20 g, 0.40 mmol) in TFA (2 mL) and CH2Cl2 (20 mL) was stirred for 9 h. After the solvent was removed under vacuum, the residue was subjected to preparative reverse-phase HPLC (VYDAC, C18) using a linear gradient of (A) water containing 0.1% TFA and (3) acetonitrile containing 0.1% TFA (0-40% B, in 120 min) at a flow rate of 15 mL/min. Fractions containing the major peak were pooled and lyophilized to yield 50 mg (26%) of (S)-3-[4-acetylamino-2-(2-quinolin-5-yl-ethoxy)-benzenesulfonylamino]-3-cyano-propionic acid. MS (APCI) m/z 483.1 (M+1).

Provenance & Evidence