Hydrochloric Acid → HCID 86588239, compound

Participants

Reaction Steps

0.103 g (0.199 mmol) N-[3-((R)-2-Indazol-1-yl-1-methyl-ethoxy)-4-(2-ethoxy-5-oxo-tetrahydro-furan-3-ylsulfamoyl)-phenyl]-acetamide was stirred in 10 mL of a mixture of 1:1 5% HCl (aq):acetonitrile at room temperature 18 hr. TLC analysis indicated complete reaction. The solvent was removed under a nitrogen flow for 5 hr. The yellow residue was triturated with a 2:1 mixture of acetone:ether. The precipitate was filtered and dried at 35° C. 18 hr to yield 0.059 g (0.113 mmol, 65.5%) of 3-[4-acetylamino-2-((R)-2-indazol-1-yl-1-methyl-ethoxy)-benzenesulfonylamino]-4-oxo-butyric acid hydrochloric acid salt. Analysis calculated for C22H24N4O7S.0.91 HCl (521.70): C, 50.33; H, 4.80; N, 10.67. Found: C, 50.27; H, 5.01; N, 10.40.

Provenance & Evidence