HCID 69691598, compound → HCID 69692657, compound

Participants

Reaction Steps

To (S)-3-{2-benzyloxy-4-[3-(2-dimethylamino-ethyl)-ureido]-benzenesulfonylamino}-4,4-diethoxy-butyric acid tert-butyl ester (1.80 g, 2.9 mmol) in ethanol (100 mL) was added 20% Pd on carbon (250 mg) and stirred under 1 atmosphere of hydrogen for 24 h. The reaction was judged complete by thin layer analysis and filtered. The filtrate was evaporated to give (S)-3-{4-[3-(2-dimethylamino-ethyl)-ureido]-2-hydroxy-benzenesulfonylamino}-4,4-diethoxy-butyric acid tert-butyl ester as a colorless foam 1.54 g (100%). MS (APCI) m/z 533.4 (M+1).

Provenance & Evidence