Ammonia → N,2-Dimethyl-3-pyridinecarboxamide

HRID 1814489Notes

Reaction equation

HRID 1814489 reaction equation
COC1C=CC(C(O)=[CH:10][C:11]2[N:20]=[CH:19][CH:18]=[CH:17][C:12]=2[C:13]([NH:15][CH3:16])=[O:14])=CC=1.N>O1CCOCC1>[CH3:10][C:11]1[N:20]=[CH:19][CH:18]=[CH:17][C:12]=1[C:13]([NH:15][CH3:16])=[O:14]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 1371829882-[2-(4-Methoxyphenyl)-2-hydroxyethenyl]-n-methylnicotinamide

Product 1

HCID 12833322N,2-Dimethyl-3-pyridinecarboxamideYield 127.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
170 °C

Procedure

2-[2-(4-Methoxyphenyl)-2-hydroxyethenyl]-N-methylnicotinamide (2.509 g) was added to a 29% aqueous solution of ammonia (100 ml) and dioxane (50 ml), which was then heated in a sealed tube at 170° C. overnight. After cooling as it was, the resulting insoluble matters were collected by filtration, to give the title compound as a dark green solid (1.694 g, yield; 73%).

Workup

  1. temperatureAfter cooling as it
  2. filtrationthe resulting insoluble matters were collected by filtration

Sources & evidence

ORD record
ord-9fba0ff5b393462fa41d396ef315301b
Source dataset
uspto-grants-2005_04
Patent number
US06875761B2

Reaction notes

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