反应详情

温度

0 °C

4-(4-Ethylpiprazin-1-yl)-6-(4-hydroxyphenyl)thieno[3,2-c]pyridine (1.10 g) was dissolved in DMF (30 ml), followed by the addition of 60% sodium hydride (0.18 g). After the evolution of hydrogen was ceased, ethyl bromoacetate (0.55 g) was added thereto, which was then stirred at 0° C. for 30 min. The reaction solution was partitioned between ethyl acetate and water. The organic layer was washed with water, dried and evaporated. The resulting residue was dissolved in THF (30 ml), followed by the addition of 3M methylmagnesium bromide/ether solution (3.3 ml) under ice-cooling, and the mixture was reacted at room temperature for 1.5 hr. The reaction solution was partitioned between ethyl acetate and water, and the aqueous layer was extracted from the organic layer with 2N hydrochloric acid. The aqueous layer was basified with 2N sodium hydroxide and back-extracted with ethyl acetate. The organic layer was washed with water, dried and evaporated. The resulting residue was purified by silica gel column chromatography (methylene chloride/methanol system) and NH-silica gel chromatography (ethyl acetate), to give the free compound of the title compound as a colorless oil (0.71 g, yield; 53.2%).

1. customThe reaction solution was partitioned between ethyl acetate and water
2. washThe organic layer was washed with water
3. customdried
4. customevaporated
5. dissolutionThe resulting residue was dissolved in THF (30 ml)
6. additionfollowed by the addition of 3M methylmagnesium bromide/ether solution (3.3 ml) under ice-
7. temperaturecooling
8. customthe mixture was reacted at room temperature for 1.5 hr
9. customThe reaction solution was partitioned between ethyl acetate and water
10. extractionthe aqueous layer was extracted from the organic layer with 2N hydrochloric acid
11. extractionback-extracted with ethyl acetate
12. washThe organic layer was washed with water
13. customdried
14. customevaporated
15. customThe resulting residue was purified by silica gel column chromatography (methylene chloride/methanol system) and NH-silica gel chromatography (ethyl acetate)