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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1814523Generated: October 25, 2026

4-(Trifluoromethoxy)benzonitrile → 3-(4-Trifluoromethoxyphenyl)isoquinolin-1-one

https://huagongshe.com/reaction/1814523

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethoxy)benzonitrileHCID 67621—
ReactantN-methyl-2-toluamideHCID 75111—
Product3-(4-Trifluoromethoxyphenyl)isoquinolin-1-oneHCID 2250322224.9%

Reaction Steps

According to the method of Example 10-1, N-methyl-2-methylbenzamide (5.97 g) and 4-trifluoromethoxybenzonitrile (7.49 g) were reacted, to give 3-(4-trifluoromethoxyphenyl)isoquinolin-1-one (3.04 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06875761B2
Source datasetuspto-grants-2005_04
ORD IDord-54ed1a1ea23141598b192ec8cc2bd622
Source noteuspto-grants-2005_04