N-methyl-2-toluamide → HCID 22503407, compound

HRID 1814525Notes

Reaction equation

HRID 1814525 reaction equation
[CH3:1][NH:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].[CH2:12]([O:19][CH2:20][CH2:21][O:22][C:23]1[CH:30]=[CH:29][C:26](C#N)=[CH:25][C:24]=1[O:31][CH3:32])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([O:19][CH2:20][CH2:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([C:1]2[NH:2][C:3](=[O:11])[C:4]3[C:5]([CH:10]=2)=[CH:6][CH:7]=[CH:8][CH:9]=3)=[CH:25][C:24]=1[O:31][CH3:32])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 75111N-methyl-2-toluamideHCID 22503524HCID 22503524, compound

Product 1

HCID 22503407HCID 22503407, compoundYield 23.6%

Procedure

According to the method of Example 10-1, N-methyl-2-methylbenzamide (5.97 g) and 4-(2-benzyloxyethoxy)-3-methoxybenzonitrile (9.57 g) were reacted, to give 3-[4-(2-benzyloxyethoxy)-3-methoxyphenyl]isoquinolin-1-one (3.20 g).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6c2b699abada4e839e4bd44af0c7aef0
Source dataset
uspto-grants-2005_04
Patent number
US06875761B2

Reaction notes

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