Sodium Hydroxide → HCID 22502674, compound

HRID 1814579Notes

Reaction equation

HRID 1814579 reaction equation
Cl.[C:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([N:20]3[CH2:25][CH2:24][N:23]([CH2:26][CH3:27])[CH2:22][CH2:21]3)[C:13]3[C:18]([CH:19]=2)=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:6][CH:5]=1)#[N:3].[OH-:28].[Na+]>S(=O)(=O)(O)O>[CH2:26]([N:23]1[CH2:22][CH2:21][N:20]([C:12]2[C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:19]=[C:10]([C:7]3[CH:6]=[CH:5][C:4]([C:2](=[O:28])[NH2:3])=[CH:9][CH:8]=3)[N:11]=2)[CH2:25][CH2:24]1)[CH3:27]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22503551HCID 22503551, compound

Product 1

HCID 22502674HCID 22502674, compoundYield 23.8%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

1-(4-Ethylpiperazin-1-yl)-3-(4-cyanophenyl)isoquinoline (1.0 g) obtained in Example 62 was reacted in concentrated sulfuric acid (40 ml) at 60° C. for 5 hr. The reaction solution was cooled and then poured over ice, and was then adjusted to pH 8 to 9 by a 8N aqueous solution of sodium hydroxide. The resulting white precipitates were collected by filtration, washed with water and dried, to give the title compound (0.25 g, yield; 23.8%).

Workup

  1. temperatureThe reaction solution was cooled
  2. additionpoured over ice
  3. customThe resulting white precipitates
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-e7510e360f814ec9acb23a31a340d2f2
Source dataset
uspto-grants-2005_04
Patent number
US06875761B2

Reaction notes

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