反应详情

To a suspension of α-cyanotolunitrile (20.0 g) in acetic acid (50 ml) was added 25% hydrogen bromide/acetate solution (150 ml), and the mixture was reacted at room temperature overnight. The resulting precipitates were collected by filtration and then added to a 10% aqueous solution of potassium carbonate. The yellow powder was changed to a pale yellow powder. The resulting powder was collected by filtration, washed with water and hexane, and dried at 50° C. under reduced pressure, to give 3-amino-1-bromoisoquinoline (28.5 g; 90.8%).

1. customthe mixture was reacted at room temperature overnight
2. customThe resulting precipitates
3. filtrationwere collected by filtration
4. additionadded to a 10% aqueous solution of potassium carbonate
5. filtrationThe resulting powder was collected by filtration
6. washwashed with water and hexane
7. customdried at 50° C. under reduced pressure