N-methyl-2-toluamide → HCID 22503579, compound

HRID 1814591Notes

Reaction equation

HRID 1814591 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[C:6]([CH3:11])=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:4].[CH2:12]([O:19][CH2:20][CH2:21][O:22][C:23]1[CH:30]=[CH:29][C:26](C#N)=[C:25]([O:31][CH3:32])[CH:24]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([O:19][CH2:20][CH2:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([C:1]2[NH:2][C:3](=[O:4])[C:5]3[C:6]([CH:11]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)=[C:25]([O:31][CH3:32])[CH:24]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 75111N-methyl-2-toluamideHCID 22502976HCID 22502976, compound

Product 1

HCID 22503579HCID 22503579, compoundYield 10.3%

Procedure

According to Example 36-1, N-methyl-o-toluamide (1.70 g) and 4-(2-benzyloxyethoxy)-2-methoxybenzonitrile (3.30 g) were reacted, to give 3-[4-(2-benzyloxyethoxy)-2-methoxyphenyl]isoquinolin-1-one (0.47 g).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b186a08353e142bfb33edd92a59d4233
Source dataset
uspto-grants-2005_04
Patent number
US06875761B2

Reaction notes

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