Sulfuric Acid → HCID 131724827, compound

Participants

Reaction Steps

Under an inert atmosphere, 4-bromobenzophenone (1.306 g, 5 mmol), and 1,4-bis(diethylphosphonomethyl)-2-dimethyloctylsilyl benzene (1.125 g, 2.05 mmol) were dissolved in tetrahydrofuran (15 g). At room temperature, tetrahydrofuran (5.46 g) solution of tert-butoxy potassium (0.690 g, 6.15 mmol) was added dropwise for 5 minutes, and successively stirred for 3.5 hours. The reaction mixture was charged into water (100 ml) and neutralized with 5% sulfuric acid. After neutralization, ethyl acetate (200 ml) was added and the organic layer was partitioned. The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resultant raw product was purified by silica gel chromatography to give the desired product. (Yield: 1.29 g, 83%)

Provenance & Evidence