反应详情

温度

25 °C

200 μmol 3-cyanophenylisocyanate dissolved in 500 μL dichloroethane was added to the above resin bound 4-[(4-cyclohexylphenylamino)methyl]-N-(2H-tetrazol-5-yl)benzamide (50 mg). Shaking the mixture for 5 hours at 25° C. followed by filtration and washing of the resin with 2×1 mL dichloromethane, 4×1 mL DMF, 2×1 mL H2O, 3×mL THF and 3×1 mL dichloromethane afforded the resin bound title compound.

1. additionwas added to the above resin
2. filtrationfollowed by filtration
3. washwashing of the resin with 2×1 mL dichloromethane, 4×1 mL DMF, 2×1 mL H2O, 3×mL THF and 3×1 mL dichloromethane
4. customafforded the resin