p-(Trifluoromethoxy)phenyl isocyanate → HCID 53639517, compound

Participants

Reaction Conditions

Reaction Steps

The above 4-[(4-carboxycyclohexylamino)methyl]benzoic acid methyl ester (1 g, 3.4 mmol) was dissolved in acetonitrile (25 mL) and 4-trifluoromethoxyphenylisocyanate (0.73 g, 3.4 mmol) was added. Stirring overnight at 50° C. followed by cooling to 25° C. formed a precipitate, which was removed by filtration. The filtrate was concentrated in vacuo and the product purified by chromatography using silica as stationary phase and a mixture of ethyl acetate, methanol and acetic acid as eluent (15:1:0.1).

Provenance & Evidence