HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1814759Generated: November 2, 2026
Hydrochloric Acid → 4-Oxo-1,4-dihydropyrimidine-5-carboxylic acid
https://huagongshe.com/reaction/1814759
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-Oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester | HCID 96347 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 4-Oxo-1,4-dihydropyrimidine-5-carboxylic acid | HCID 15136786 | 89.3% |
Reaction Steps
Ethyl 3,4-dihydro-4-oxopyrimidine-5-carboxylate (K R Huffman, F C Schaefer and G A Peters, J. Org. Chem. (1962) 27, 551-8) (1.68 g) was dissolved in 1N NaOH (23 ml) and heated at 60° C. overnight. After cooling in ice, the solution was acidified to pH2 with 2N HCl, stirred 5 mins and the solid filtered off and dried under vacuum to give title compound (1.25 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06878704B2 |
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| Source dataset | uspto-grants-2005_04 |
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| ORD ID | ord-251c13cbe65e4f728a9cc85843493766 |
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| Source note | uspto-grants-2005_04 |
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