HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 3-Chloro-6-(chloromethyl)pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 3-Chloro-6-methylpyridazine | HCID 227254 | — |
| Catalyst | Benzoyl Peroxide | HCID 7187 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 3-Chloro-6-(chloromethyl)pyridazine | HCID 22498639 | 43.9% |
Reaction Steps
A suspension of 3-chloro-6-methylpyridazine (3 g), benzoyl peroxide (150 mg) and N-chlorosuccinimide (3.12 g) in CCl4 (30 ml) was refluxed 16 hours, cooled, filtered and evaporated. Chromatography (EtOAc/hexane) gave title compound (1.67 g). NMR δ(CDCl3) 4.87 (2H, s), 7.58 (1H, d), 7.71 (1H, d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06878704B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-9e0c875016194aaabcfe3709d8b2f394 |
| Source note | uspto-grants-2005_04 |