tert-butyl 5-nitro-2,3-dihydro-1H-inden-2-ylcarbamate → tert-butyl N-(5-amino-2,3-dihydro-1H-inden-2-yl)carbamate

Participants

Reaction Steps

A solution of (5-nitro-indan-2-yl)-carbamic acid tert-butyl ester (3.52 g, 12.6 mmol) in ethanol (100 mL) is degassed and 10% palladium on carbon added. The reaction is evacuated and placed under 1 atm H2(g) for 2 h. Filtration of the reaction mixture through Celite is followed by concentration of the filtrate under reduced pressure to give (5-amino-indan-2-yl)-carbamic acid tert-butyl ester as an oil which is used directly without further purification.

Provenance & Evidence