HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-chloronicotinate → 2-(4-Trifluoromethyl-phenyl)-nicotinic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-chloronicotinate | HCID 819931 | — |
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 2-(4-Trifluoromethyl-phenyl)-nicotinic acid methyl ester | HCID 53950991 | — |
Reaction Steps
2-(4-Trifluoromethyl-phenyl)-nicotinic acid methyl ester is prepared by palladium [PdCl2 (dppf)] catalyzed coupling of 2-chloronicotinic acid methyl ester (1.45 g, 8.45 mmol) and 4-trifluoromethylbenzeneboronic acid (2.41 g, 12.68 mmol) to give an oil: 1H NMR (CDCl3, 300 MHz): δ 8.80 (1H dd), 8.19 (1H, dd), 7.67 (4H, q), 7.40 (1H, dd), 3.70 (3H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06878707B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-ac6f497a3e8d48899ee1e822bf022c00 |
| Source note | uspto-grants-2005_04 |