Sodium Hydroxide → 4-Bromobenzylamine

Participants

Reaction Steps

4-Bromobenzylamine hydrochloride (500 mg) was dissolved in water (25 mL) and 1 M NaOH (2 mL) was added. The mixture was extracted with CH2Cl2 (3×30 mL) and the combined organic layers were concentrated in vacuo to a clear oil. The resulting 4-bromobenzylamine afforded 51 mg of the title compound as a white solid. Physical characteristics. 1H NMR (300 MHz, DMSO-d6) δ 10.54, 8.54, 7.54-7.51, 7.29-7.26, 6.85, 6.36, 6.25, 5.24, 4.68, 4.50, 3.90, 3.75-3.67, 2.77-2.65, 2.28; HRMS (ESI) m/z 514.0994 (M+H)+.

Provenance & Evidence