N-(4-Chlorobenzyl)-2-(chloromethyl)-7-methyl-4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide → HCID 22498724, compound

HRID 1814876Notes

Reaction equation

HRID 1814876 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:11](=[O:22])[C:12]3[CH:19]=[C:18]([CH2:20]Cl)[O:17][C:13]=3[N:14]([CH3:16])[CH:15]=2)=[O:9])=[CH:4][CH:3]=1.[CH3:25][NH:26][CH2:27][CH:28]([C:30]1[C:35]([F:36])=[CH:34][C:33]([F:37])=[CH:32][C:31]=1[F:38])[OH:29]>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:11](=[O:22])[C:12]3[CH:19]=[C:18]([CH2:20][N:26]([CH2:27][CH:28]([OH:29])[C:30]4[C:31]([F:38])=[CH:32][C:33]([F:37])=[CH:34][C:35]=4[F:36])[CH3:25])[O:17][C:13]=3[N:14]([CH3:16])[CH:15]=2)=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10126210N-(4-Chlorobenzyl)-2-(chloromethyl)-7-methyl-4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamideHCID 10214466HCID 10214466, compound

Product 1

HCID 22498724HCID 22498724, compound

Procedure

Analogous to the procedures described in Example 38, N-(4-chlorobenzyl)-2-(chloromethyl)-7-methyl-4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide (Example 2) is treated with rac-2-(methylamino)-1-(2,4,6-trifluorophenyl)ethanol (Preparation 44) to afford the title compound.

Sources & evidence

ORD record
ord-9b627a5d9e4d4fc6b290cde79c37d118
Source dataset
uspto-grants-2005_04
Patent number
US06878705B2

Reaction notes

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