N-(4-Chlorobenzyl)-2-(chloromethyl)-7-methyl-4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide → HCID 20772304, compound

HRID 1814885Notes

Reaction equation

HRID 1814885 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:11](=[O:22])[C:12]3[CH:19]=[C:18]([CH2:20]Cl)[O:17][C:13]=3[N:14]([CH3:16])[CH:15]=2)=[O:9])=[CH:4][CH:3]=1.[O:25]1[CH:29]=[CH:28][CH:27]=[C:26]1[CH:30]([CH:32]1[CH2:36][CH2:35][CH2:34][NH:33]1)[OH:31]>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:11](=[O:22])[C:12]3[CH:19]=[C:18]([CH2:20][N:33]4[CH2:34][CH2:35][CH2:36][C@@H:32]4[C@H:30]([C:26]4[O:25][CH:29]=[CH:28][CH:27]=4)[OH:31])[O:17][C:13]=3[N:14]([CH3:16])[CH:15]=2)=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10126210N-(4-Chlorobenzyl)-2-(chloromethyl)-7-methyl-4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamideHCID 22498718HCID 22498718, compound

Product 1

HCID 20772304HCID 20772304, compound

Procedure

Analogous to the procedures described in Example 59, N-(4-chlorobenzyl)-2-(chloromethyl)-7-methyl-4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide (Example 2) is treated with 2-furyl(pyrrolidin-2-yl)methanol (Preparation 73) to afford the title compound.

Sources & evidence

ORD record
ord-0b9cdbb8b61c4b348a87fad1138e90f9
Source dataset
uspto-grants-2005_04
Patent number
US06878705B2

Reaction notes

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