HCID 10237594, compound → HCID 10127702, compound

HRID 1814899Notes

Reaction equation

HRID 1814899 reaction equation
Br[C:2]1[O:23][C:5]2[N:6]([CH3:22])[CH:7]=[C:8]([C:11]([NH:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)=[O:12])[C:9](=[O:10])[C:4]=2[CH:3]=1.[N:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH:30]([OH:34])[CH2:31][C:32]#[CH:33]>>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([CH2:14][NH:13][C:11]([C:8]2[C:9](=[O:10])[C:4]3[CH:3]=[C:2]([C:33]#[C:32][CH2:31][CH:30]([OH:34])[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][N:24]=4)[O:23][C:5]=3[N:6]([CH3:22])[CH:7]=2)=[O:12])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 10237594HCID 10237594, compoundHCID 22498709HCID 22498709, compound

Product 1

HCID 10127702HCID 10127702, compound

Procedure

Analogous to the procedures described in Example 88, 2-bromo-N-(4-chlorobenzyl)-7-methyl-4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide (Example 79) is treated with 1-(pyridin-2-yl)but-3-yn-1-ol (Preparation 76) to afford the title compound.

Sources & evidence

ORD record
ord-15d3923134764e5c809f51bcf022aa37
Source dataset
uspto-grants-2005_04
Patent number
US06878705B2

Reaction notes

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