HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methyl-2-nitrobenzoic acid → Methyl 2-methyl-6-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methyl-2-nitrobenzoic acid | HCID 16097 | — |
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Product | Methyl 2-methyl-6-nitrobenzoate | HCID 596057 | — |
Reaction Steps
2-Methyl-6-nitrobenzoic acid is reacted with trimethylsilyldiazomethane to yield methyl 2-methyl-6-nitrobenzoate with m.p. 44-45° (Chem. Pharm. Bull., Vol. 29, 1475 (1981)). Methyl 2-methyl-6-nitrobenzoate is hydrogenated in methanol in the presence of palladium, 10% on carbon powder, at room temperature and atmospheric pressure to give methyl 2-methyl 6-aminobenzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06878720B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-444c06fc1f4a4906bcae1e0ee116f207 |
| Source note | uspto-grants-2005_04 |