HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-hydroxypiperidine-1-carboxylate → HCID 22499493, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | 4-Chloro-2-pyridinecarbonitrile | HCID 693342 | — |
| Reactant | 1-Boc-4-(2-pyridyloxy)piperidine | HCID 21906039 | — |
| Product | HCID 22499493 | HCID 22499493 | — |
Reaction Steps
Prepared from 1-Boc-4-hydroxypiperidine and 4-chloro-2-cyanopyridine using methods substantially equivalent to those described for the synthesis of 1-Boc-4-(pyridin-2-yloxy)piperidine. The product was purified by chromatography over silica gel, eluting with 25% ethyl acetate in hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06878725B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-679bdf95e6bc46ebb97013f345e4408f |
| Source note | uspto-grants-2005_04 |