HCID 22499792, compound → HCID 22499800, compound

Participants

Reaction Steps

The title compound was prepared analogously to example 1, except 6-(2-cyclopentyl-2-hydroxy-4-thiazol-2-yl-but-3-ynyl)-2,2-dimethyl-[1,3]dioxin-4-one (from Step 1) was used rather than 6-[2-cyclopentyl-2-hydroxy-4-(4-methoxy-phenyl)-but-3-ynyl]-2,2-dimethyl-[1,3]dioxin-4-one. 1H NMR (CDCl3): δ 1.63-2.05 (bm, 4H), 2.23 (pentet, 1H, J=8.1 Hz), 2.78 (d, 1H, J=17.7 Hz), 3.04 (d, 1H, J=17.7 Hz), 3.51 (d, 1H, J=20.0 Hz), 3.97 (d, 1H, J=20.0 Hz), 7.46 (d, 1H, J=3.2 Hz), 7.89 (d, 2H, J=3.4 Hz). Anal. Calcd. for C15H15N1O3S1.0.25 H2O: C, 57.75; H, 4.93; N, 4.35. Found: C, 58.2; H, 5.34; N, 4.36; ESIMS (M+Na+): 312.0.

Provenance & Evidence