Ethanol → tert-butyl N-[4-(pyrrolidin-3-ylcarbamoylamino)cyclohexyl]carbamate

HRID 181514Notes

Reaction equation

HRID 181514 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][CH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15](=[O:16])[NH:17][CH:18]2[CH2:19][N:20]([CH2:23][c:24]3[cH:25][cH:26][cH:27][cH:28][cH:29]3)[CH2:21][CH2:22]2)[CH2:12][CH2:13]1)=[O:30].[CH3:31][CH2:32][OH:33].[OH-:34].[OH-:36].[Pd+2:35]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][CH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15](=[O:16])[NH:17][CH:18]2[CH2:19][NH:20][CH2:21][CH2:22]2)[CH2:12][CH2:13]1)=[O:30]

Participants

5

Reactant 4

HCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 67022948tert-butyl N-[4-[(1-benzylpyrrolidin-3-yl)carbamoylamino]cyclohexyl]carbamate

Product 1

HCID 67022939tert-butyl N-[4-(pyrrolidin-3-ylcarbamoylamino)cyclohexyl]carbamate

Sources & evidence

ORD record
ord-2f403db531e84436a20de7579888c93d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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