反应详情

Quinolin-6-yl-methanol (7.7 g, 48 mmol) was dissolved in benzene (3 mL) and SOCl2 (20 mL) was added at 0° C. The mixture was stirred at RT for 1 h, then heated to reflux and stirred an additional 1 h. The mixture was cooled to RT and the solid was filtered to give the 6-chloromethyl-quinoline.

1. temperatureheated
2. temperatureto reflux
3. stirringstirred an additional 1 h
4. temperatureThe mixture was cooled to RT
5. filtrationthe solid was filtered