1,2-Dichloroethane → HCID 10291174, compound

Participants

Reaction Steps

To a mixture of the thienyl carboxylic acid from Step A (300 mg, 1.23 mmol) and 4-chloroaniline (160 mg, 1.25 mmol) and DIEA (300 μl, 1.6 mmol) was added EDC (300 mg, 1.6 mmol) and HOBt (170 mg, 1.25 mmol) in CH2Cl2, the reaction was stirred at RT overnight. The solution was washed with 1N HCl and saturated NaHCO3, followed by H2O and brine. The organic layer was dried over Na2SO4 and evaporated under reduced pressure and purified with preparative TLC to give the amide. MS (ES+): 353 (M+H)+; (ES−): 351 (M−H)−.

Provenance & Evidence