4-Tert-Butylaniline → HCID 85890745, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Tert-Butylaniline	HCID 69861	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	3,6-Dichloropyridazine-4-carboxylic acid	HCID 433804	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 85890745	HCID 85890745	—

Reaction Steps

3,6-Dichloro-pyridazine-4-carboxylic acid (1.93 g, 10 mmol), 4-tert-Butyl-phenylamine (1.49 g, 10 mmol), DIEA (3.5 mL, 20 mmol), and HATU (4.56 g, 12 mmol) were added to DMF (20 mL). The reaction was stirred at rt for 15 h. The resulting dark brown solution was extracted with DCM (2×10 mL), washed with H2O (2×10 mL), and dried over sodium sulfate. The curde product was further purified using Flash Chromatography (2% MeOH/DCM), affording the desired product as yellow solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06878714B2
Source dataset	uspto-grants-2005_04
ORD ID	ord-90d003de5a0e4b599f695071112f5b0d
Source note	uspto-grants-2005_04