HCID 69744124, compound → HCID 135718994, compound

HRID 1815215Notes

Reaction equation

HRID 1815215 reaction equation
C[O:2][C:3](=[O:47])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10](N(C(C2N(OCC3C=CC=CC=3)C(C3CCCCC3)NC=2COC23CC4CC(CC(C4)C2)C3)=O)N)=O)[CH:5]=1.[C:48]12([O:58][CH2:59][C:60]3[NH:64][CH:63]([CH:65]4[CH2:70][CH2:69][CH2:68][CH2:67][CH2:66]4)[N:62]([O:71]CC4C=CC=CC=4)[C:61]=3[C:79]([NH:81][NH2:82])=[O:80])[CH2:57][CH:52]3[CH2:53][CH:54]([CH2:56][CH:50]([CH2:51]3)[CH2:49]1)[CH2:55]2.C12(OCC3NC(C4CCCCC4)=NC=3C(NN)=O)CC3CC(CC(C3)C1)C2>>[C:48]12([O:58][CH2:59][C:60]3[NH:64][CH:63]([CH:65]4[CH2:66][CH2:67][CH2:68][CH2:69][CH2:70]4)[N:62]([OH:71])[C:61]=3[C:79]3[O:80][C:10]([C:6]4[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=4)[C:3]([OH:47])=[O:2])=[N:82][N:81]=3)[CH2:55][CH:54]3[CH2:56][CH:50]([CH2:51][CH:52]([CH2:53]3)[CH2:57]1)[CH2:49]2

Participants

4

Reactant 3

HCID 69744124HCID 69744124, compoundHCID 69744154HCID 69744154, compoundHCID 69744697HCID 69744697, compound

Product 1

HCID 135718994HCID 135718994, compound

Procedure

3-{N1-[5-(Adamantan-1-yloxymethyl)-3-benzyloxy-2-cyclohexyl-1H-imidazole-4-carbonyl]-hydrazinocarbonyl}-benzoic acid methyl ester. The title compound was prepared essentially using the procedure in Example 8, step b, with the modification that 5-(Adamantan-1-yloxymethyl)-3-benzyloxy-2-cyclohexyl-1H-imidazole-4-carboxylic acid hydrazide. was used instead of 5-(Adamantan-1-yloxymethyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid hydrazide. 1H NMR (CDCl3) 11.16 (1H, d), 9.21 (1H, br s), 8.51 (1H, s), 8.20 (1H, d), 8.12 (1H, d), 7.54 (1H, t), 7.46 (2H, m), 7.38 (3H, m), 5.33 (2H, s), 4.74 (2H, s), 3.94 (3H, s), 2.60 (1H, m), 2.17 (3H, br s), 1.90 (6H, s), 1.79 (2H, m), 1.62 (11H, m), 1.26 (3H, m).

Sources & evidence

ORD record
ord-cff259f98feb4eabb0ba527b3d7ed80c
Source dataset
uspto-grants-2005_04
Patent number
US06878734B2

Reaction notes

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