Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Oxindole | HCID 321710 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 5-acetyl-2,3-dihydro-1H-indol-2-one | HCID 10219643 | 73% |
Reaction Steps
2-Oxindole (3 g) was suspended in 1,2-dichloroethane and 3.2 mL acetyl chloride were slowly added. The resulting suspension was heated to 50° C. for 5 hours, cooled, and poured into water. The resulting precipitate was collected by vacuum filtration, washed copiously with water and dried under vacuum to give 2.9 g (73% yield) of the title compound as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06878733B1 |
|---|
| Source dataset | uspto-grants-2005_04 |
|---|
| ORD ID | ord-a5e51818525e4c38b3990283b4736005 |
|---|
| Source note | uspto-grants-2005_04 |
|---|
