N-Methyloxindole → HCID 67281554, compound

HRID 1815279Notes

Reaction equation

HRID 1815279 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][C:3]1=[O:11].[CH:12]([C:14]1[NH:18][C:17]([C:19]([OH:21])=[O:20])=[CH:16][C:15]=1[CH3:22])=O>>[CH3:22][C:15]1[CH:16]=[C:17]([C:19]([OH:21])=[O:20])[NH:18][C:14]=1[CH:12]=[C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:2]([CH3:1])[C:3]1=[O:11]

Participants

3

Reactant 2

HCID 6096N-MethyloxindoleHCID 98988845-formyl-4-methyl-1H-pyrrole-2-carboxylic Acid

Product 1

HCID 67281554HCID 67281554, compoundYield 88.6%

Procedure

1-Methyl-1,3-dihydroindol-2-one (147 mg, 1 mmol) was condensed with 5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid (153 mg) using method D to give 250 mg (86%) of the title compound.

Sources & evidence

ORD record
ord-5c786c7e04b84d86a684c3a014721348
Source dataset
uspto-grants-2005_04
Patent number
US06878733B1

Reaction notes

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