5-Methoxyoxindole → HCID 86759636, compound

HRID 1815290Notes

Reaction equation

HRID 1815290 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH2:6]2.[CH2:13]([N:15]([CH2:30]C)[CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]1[NH:23][C:24]([CH:28]=O)=[CH:25][C:26]=1[CH3:27])=[O:21])C>>[CH3:30][N:15]([CH3:13])[CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]1[NH:23][C:24]([CH:28]=[C:6]2[C:5]3[C:9](=[CH:10][CH:11]=[C:3]([O:2][CH3:1])[CH:4]=3)[NH:8][C:7]2=[O:12])=[CH:25][C:26]=1[CH3:27])=[O:21]

Participants

3

Reactant 2

HCID 15142865-MethoxyoxindoleHCID 865861965-formyl-3-methyl-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl) amide

Product 1

HCID 86759636HCID 86759636, compoundYield 39%

Procedure

5-Methoxy-1,3-dihydroindol-2-one (82.5 mg, 0.5 mmol) was condensed with 5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl)amide to give 80 mg (39%) of the title compound.

Sources & evidence

ORD record
ord-05c25d62390e4166b452b70a60fb7519
Source dataset
uspto-grants-2005_04
Patent number
US06878733B1

Reaction notes

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