5-Bromo-2-oxindole → HCID 67280805, compound

HRID 1815299Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:32][CH3:33])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[NH:22][C:23]([CH:30]=O)=[C:24]([C:27](=[O:29])[CH3:28])[C:25]=1[CH3:26])=[O:20])[CH3:13].C(OC(C1NC(C=O)=C(C(=O)C)C=1C)=O)C>>[CH2:32]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[NH:22][C:23]([CH:30]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])=[C:24]([C:27](=[O:29])[CH3:28])[C:25]=1[CH3:26])=[O:20])[CH3:33]

Participants

Reactant 3

HCID 6111935-Bromo-2-oxindole

HCID 768653HCID 768653, compound

HCID 86586201HCID 86586201, compound

Product 1

HCID 67280805HCID 67280805, compound

Procedure

5-Bromo-1,3-dihydro-indol-2-one was condensed with 4-acetyl-5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl)amide (prepared from 4-acetyl-5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid ethyl ester by method B then C) to give the title compound.

Sources & evidence

ORD record: ord-97dbed15e4ac4477ba5c7309b0e66264
Source dataset: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06878733B1

Reaction notes

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