5-Bromo-2-oxindole → HCID 67281636, compound

HRID 1815304Notes

Reaction equation

HRID 1815304 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH:12]([C:14]1[NH:18][C:17]([CH:19]([CH3:21])[CH3:20])=[C:16]([C:22]([OH:24])=[O:23])[C:15]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[CH:12][C:14]1[NH:18][C:17]([CH:19]([CH3:21])[CH3:20])=[C:16]([C:22]([OH:24])=[O:23])[C:15]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 21915645HCID 21915645, compound

Product 1

HCID 67281636HCID 67281636, compoundYield 58.4%

Procedure

5-Bromo-1,3-dihydroindol-2-one (170 mg, 0.8 mmol) was condensed with 5-formyl-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid (205 mg) using method D to give 210 mg (58%) of the title compound as a yellow solid.

Sources & evidence

ORD record
ord-39c5814236e344c4a19f383bddecfec1
Source dataset
uspto-grants-2005_04
Patent number
US06878733B1

Reaction notes

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