5-Bromo-2-oxindole → HCID 67281072, compound

HRID 1815336Notes

Reaction equation

HRID 1815336 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:19][CH3:20])[CH2:15][CH2:16][CH2:17][NH2:18])[CH3:13].[CH:21]([C:23]1[NH:27][C:26]([CH:28]([CH3:30])[CH3:29])=[C:25]([C:31](O)=[O:32])[C:24]=1[CH:34]([CH3:36])[CH3:35])=O>>[CH2:12]([N:14]([CH2:19][CH3:20])[CH2:15][CH2:16][CH2:17][NH:18][C:31]([C:25]1[C:24]([CH:34]([CH3:35])[CH3:36])=[C:23]([CH:21]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])[NH:27][C:26]=1[CH:28]([CH3:30])[CH3:29])=[O:32])[CH3:13]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86759638HCID 86759638, compound

Product 1

HCID 67281072HCID 67281072, compoundYield 25.8%

Procedure

5-Bromo-1,3-dihydroindol-2-one (90 mg, 0.42 mmol) was conducted with 5-formyl-2,4-diisopropyl-1H-pyrrole-3-carboxylic acid (3-diethylaminopropyl)amine (140 mg) to give 54 mg (25%) of the title compound as red-brown solid.

Sources & evidence

ORD record
ord-3e4b43583b32486ea488538629eba608
Source dataset
uspto-grants-2005_04
Patent number
US06878733B1

Reaction notes

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