HRID1815345

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C1Cc2cc(S(=O)(=O)Nc3cccc(Cl)c3)ccc2N1

HCID9055843

T5557536

C14H11ClN2O3S

HCID20761729

未命名化合物

PRODUCTS

生成物

结构：Cc1[nH]c(C=C2C(=O)Nc3ccc(S(=O)(=O)Nc4cccc(Cl)c4)cc32)c(C)c1C(=O)NCCN1CCCC1

HCID67281583

未命名化合物

收率 69.5%

PROCEDURE

实验过程

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)amide (120 mg, 0.38 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-ylethyl)amide (100 mg) to give 150 mg (69%) of the title compound as a yellow orange solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-99795aed179d42d6b9cc413447c2cdad
来源数据集: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06878733B1
来源说明: uspto-grants-2005_04

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][S:9]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16](=[O:21])[CH2:15]3)(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[N:22]1([CH2:27][CH2:28][NH:29][C:30]([C:32]2[C:36]([CH3:37])=[C:35]([CH:38]=O)[NH:34][C:33]=2[CH3:40])=[O:31])[CH2:26][CH2:25][CH2:24][CH2:23]1>>[N:22]1([CH2:27][CH2:28][NH:29][C:30]([C:32]2[C:36]([CH3:37])=[C:35]([CH:38]=[C:15]3[C:14]4[C:18](=[CH:19][CH:20]=[C:12]([S:9](=[O:11])(=[O:10])[NH:8][C:4]5[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=5)[CH:13]=4)[NH:17][C:16]3=[O:21])[NH:34][C:33]=2[CH3:40])=[O:31])[CH2:26][CH2:25][CH2:24][CH2:23]1