HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 67282350, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-methyl-2-oxoindoline-5-sulfonamide | HCID 10176909 | — |
| Reactant | HCID 85786887 | HCID 85786887 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67282350 | HCID 67282350 | 54.8% |
Reaction Steps
A mixture of [(5-formyl-4-methyl-1H-pyrrole-3-carbonyl)-amino]-acetic acid ethyl ester (0.142 g, 0.59 mmol) and 1N NaOH (1.2 mL) in methanol (10 mL) was stirred at room temperature for 1 hr. The reaction was concentrated and the residue was condensed with 5-methylaminosulfonyl-2-oxindole (0.13 g, 0.48 mmol) and piperidine (0.12 mL) in ethanol (12 mL) to give 0.11 g (52%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06878733B1 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-d32e4a62980343fa9b3d391437d8f404 |
| Source note | uspto-grants-2005_04 |