Hydrochloric Acid → HCID 12150533, compound

Participants

Reaction Steps

Ethyl 6-(2-benzofuranyl)-2,3-dihydro-2,2-dimethyl-1-methoxy-7-phenyl-1H-pyrrolizin-5-yl-2-oxoacetate (example 21b, 0.92 g, 2 mmol) in diethylene glycol (20 ml) is heated at 60° C. for 30 min. with hydrazine hydrate 80% (1.56 ml, 40 mmol), then treated with KOH techn. 85% (2.1 g, 32 mmol) and the mixture is kept at 130° C. for 4 h (until the end of the evolution of gas and fading of the coloration). The mixture, which is poured onto ice, is brought to pH 3 using HCl 10%, and the fine precipitate is filtered off with suction and dried over P2O5.

Provenance & Evidence