Chloroform → HCID 22500689, compound

HRID 1815437Notes

Reaction equation

HRID 1815437 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:15](=[O:16])[N:14]3[CH:10]([CH2:11][C:12]([CH3:18])([CH3:17])[CH2:13]3)[C:9]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:4][CH:3]=1.C(Cl)(Cl)Cl.ClC1C=CC(C2C(=[O:44])N3C(=CC(C)(C)C3)C=2C2C=CC=CC=2)=CC=1>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:15](=[O:16])[N:14]3[C:10]([OH:44])([CH2:11][C:12]([CH3:17])([CH3:18])[CH2:13]3)[C:9]=2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 22500681HCID 22500681, compoundHCID 22500700HCID 22500700, compound

Product 1

HCID 22500689HCID 22500689, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

It was not possible to observe the 2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,6,7,7a-tetrahydro-pyrrolizin-3-one (keto tautomer of 2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-ol) expected as a hydrolysis product in any case. After relatively long standing (16 h) of a CHCl3 solution of the product, the 2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,6-dihydropyrrolizin-3-one described in example 29 is obtained as a substance in pure form (H2O elimination).

Sources & evidence

ORD record
ord-955507a2ff21444f85ce4c54c68e11d5
Source dataset
uspto-grants-2005_04
Patent number
US06878738B1

Reaction notes

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