Hydrochloric Acid → HCID 178478779, compound

Participants

Reaction Steps

A solution of the product of step b (1.14 g, 2.00 mmol) in 1,4-dioxan (5 ml) was treated with hydrogen chloride in 1,4-dioxan (15 ml) and the reaction mixture stirred at ambient temperature for 16 h. The solvent was evaporated at reduced pressure. The residue was evaporated from DCM (30 ml) to give the title compound (700 mg, 95%). 1H NMR (DMSO-d6) 10.97 (1H, br s), 8.29 (1H, br s), 8.07 (1H, t, 6), 7.69 (2H, br s), 7.40 (2H, d, 8.4), 7.30 (2H, d, 8.4), 4.37 (2H, s), 3.48-3.45 (2H, m), 3.24-3.20 (2H, m), 3.08-3.03 (2H, m), 2.94-2.91 (2H, m), 2.00-1.84 (6H, m). Microanalysis found C 48.91 H 6.95 N 14.99. C15H25Cl3N4 requires C 48.99 H 6.85 N 15.24.

Provenance & Evidence