1-Pyrrolidinepropanamine → HCID 178512192, compound

Participants

Reaction Steps

A solution of the product of step b (986 mg, 3.00 mmol) and N-(3-aminopropyl)-pyrrolidine (0.948 ml, 7.50 mmol) in ethanol (10 ml) was heated at reflux for 16 h. The solvent was removed at reduced pressure and the residue suspended in aqueous ammonia (880, 25 ml). The solid was removed by filtration and the filter-cake washed sequentially with water (50 ml) and diethyl ether (50 ml) to give the title compound as a white solid (585 mg, 69%). 1H NMR (DMSO-6) 7.18-7.12 (2H, m), 6.76-6.66 (2H, m), 5.8-4.8 (3H, br s), 3.12 (2H, t, 6.9), 2.43-2.36 (6H, m), 1.69-1.56 (6H, m). Microanalysis found C 60.01 H 7.62 N 19.74. C14H21ClN4 requires C 59.88 H 7.54 N 19.95.

Provenance & Evidence