1-Pyrrolidinepropanamine → HCID 178484961, compound

Participants

Reaction Steps

A solution of the product from step b (358 mg, 1.00 mmol) and 3-pyrrolidin-1-yl-propylamine (0.19 ml) in ethanol (4 ml) was stirred at ambient temperature for 16 h followed by heating at reflux for 1 h. The solvent was removed at reduced pressure and the residue was partitioned between DCM (20 ml) and aqueous ammonia (880, 20 ml). The aqueous phase was extracted with further DCM (10 ml) and then discarded. The combined organic phases were washed twice with water (20 ml) and once with brine (20 ml). The organic phase was dried over anhydrous sodium sulfate and the filtrate evaporated to afford the title compound (225 mg, 73%). 1H NMR 7.40-7.29 (4H, m), 4.60 (2H, s), 3.42-3.47 (2H, m), 2.97 (3H, s), 2.50-2.44 (6H, m), 1.83-1.63 (6H, m).

Provenance & Evidence