Triethylamine → HCID 13471176, compound

Participants

Reaction Steps

0.55 mmol of triethylamine and 0.37 mmol of benzyl chloroformate are added in succession to a solution of 0.25 mmol of (5R,5aS,8aS,9S)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3′,4′:6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one in 10 ml of anhydrous dichloromethane at 0° C. and under argon. After stirring for 1 hour, the reaction mixture is washed with water. The organic phase is then dried, filtered and subsequently concentrated under reduced pressure. Chromatography on silica gel (cyclohexane/ethyl acetate: 60/40) enables the expected product to be isolated.

Provenance & Evidence