2-Chlorobenzaldehyde → HCID 11664188, compound

Participants

Reaction Steps

The title compound was prepared by the procedures described in Example 1 substituting 2,4-dichlorothiophenol with 2-bromothiophenol, 2-chlorobenzaldehyde with 4-fluoro-3-trifluoromethylbenzaldehyde, and 6-amino-1-hexanol with t-butyl 1-piperazinecarboxylate, to give a white solid. 1H NMR (CDCl3, 300 MHz) d 1.48 (s, 9H), 3.49 (br s, 4H), 3.56-3.78 (m, 4H), 6.89 (d, J=15.6 Hz, 1H), 7.10 (d, J=8.4 Hz, 1H), 7.18-7.35 (m, 3H), 7.49 (d, J=8.4 Hz, 1H), 7.65 (d, J=15.6 Hz, 1H), 7.68 (dd, J=2.1, 8.4 Hz, 1H), 7.85 (br s, 1H). MS (APCI−) (M+Cl)− at m/z 605, 607, 609. Anal. Calcd for C25H26N2O3BrF3S. 0.03 H2O: C, 52.50; H, 4.59; N, 4.90. Found: C, 52.54; H, 4.71; N, 4.68.

Provenance & Evidence